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pentobarbital will reduce the extent or influence of fostemsavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.Barbiturates can induce hepatic microsomal enzymes leading to enhanced metabolism and reduced anticoagulant reaction of oral anticoagulants (eg, warfarin, acenocoumarol, dicumarol, and phenprocoumon); people sta